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Acute toxic effects of fragrance
products.
Anderson RC, Anderson
JH.
Anderson Laboratories, Inc., West Hartford, Vermont,
USA.
To evaluate whether fragrance products can produce acute
toxic effects in mammals, we allowed groups of male Swiss-Webster mice
to breathe the emissions of five commercial colognes or toilet water for
1 h. We used the ASTM-E-981 test method to evaluate sensory irritation
and pulmonary irritation. We used a computerized version of this test to
measure the duration of the break at the end of inspiration and the
duration of the pause at the end of expiration. Decreases in expiratory
flow velocity indicated airflow limitation. We subjected the mice to a
functional observational battery to probe for changes in nervous system
function. The emissions of these fragrance products caused various
combinations of sensory irritation, pulmonary irritation, decreases in
expiratory airflow velocity, as well as alterations of the functional
observational battery indicative of neurotoxicity. Neurotoxicity was
more severe after mice were repeatedly exposed to the fragrance
products. Evaluation of one of the test atmospheres with gas
chromatography/mass spectrometry revealed the presence of chemicals for
which irritant and neurotoxic properties had been documented previously.
In summary, some fragrance products emitted chemicals that caused a
variety of acute toxicities in mice.
PMID: 9577937 [PubMed -
indexed for MEDLINE]
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